Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ACE | P12821 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CFTR | P13569 | 2/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29715382 | 0.90 | LMNA (0.55) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL4111979 | 0.90 | TDP1 (0.62) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL23093165 | 0.90 | LMNA (0.55) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8698541 | 0.88 | LMNA (0.58) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL4118662 | 0.86 | MEN1 (0.66) | LMNAPKMGAASMN1; SMN2ACE | |
| SCHEMBL8383957 | 0.86 | MEN1 (0.66) | LMNAPKMGAASMN1; SMN2ACE | |
| SCHEMBL8722562 | 0.86 | POLB (0.65) | LMNAPKMGAAACEMEN1 | |
| SCHEMBL10849527 | 0.85 | LMNA (0.47) | LMNAPKMGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL3840630 | 0.85 | ACE (0.61) | LMNAALDH1A1ACEPOLBTDP1 | |
| SCHEMBL8908771 | 0.85 | ACE (0.61) | LMNAALDH1A1ACEPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952328-A | MAY BE USED TO ALLEVIATE, MEDIATE, REDUCE AND/OR PREVENT DISORDERS WHICH ARE ASSOCIATED WITH ABNORMAL AND/OR ABERRANT ACTIVITY OF CYSTEINE PROTEASES AND/OR SERINE PROTEASES | CEPHALON, INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0161102-B1 | ISOQUINOLINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-02-21 | — | — | EP | disclosed |
| US-4835158-A | Isoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1989-05-30 | — | — | US | disclosed |
| EP-0161102-A2 | Isoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1985-11-13 | — | — | EP | disclosed |