Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902847 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HSD17B10SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL20456353 | 0.82 | NOTUM (0.42) | ALDH1A1NOTUMLMNA | |
| SCHEMBL2378473 | 0.76 | CA12 (0.45) | ALDH1A1SMN1; SMN2KDM4EKMT2ATSHR | |
| SCHEMBL13383600 | 0.73 | LMNA (0.47) | HSD17B10KDM4EMAPTNOTUMTSHR | |
| SCHEMBL18924943 | 0.72 | ALDH1A1 (0.49) | ALDH1A1HSD17B10SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL28123975 | 0.72 | TSHR (0.51) | ALDH1A1HSD17B10SMN1; SMN2NOTUMTSHR | |
| SCHEMBL4593908 | 0.71 | LMNA (0.46) | ALDH1A1HSD17B10KDM4EMAPTNOTUM | |
| SCHEMBL1231703 | 0.71 | CA12 (0.39) | TSHR | |
| SCHEMBL1862926 | 0.71 | CA12 (0.39) | TSHR | |
| SCHEMBL6646583 | 0.71 | CA12 (0.48) | ALDH1A1SMN1; SMN2KDM4EKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | claimed |