Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093283 | 0.90 | LMNA (0.52) | LMNAACE | |
| SCHEMBL29715343 | 0.90 | LMNA (0.52) | LMNAACE | |
| SCHEMBL15124641 | 0.86 | LMNA (0.64) | LMNAACE | |
| SCHEMBL29443075 | 0.85 | ACE (0.61) | ACE | |
| SCHEMBL8633111 | 0.85 | ACE (0.61) | ACE | |
| SCHEMBL11077397 | 0.82 | ACE (0.58) | ACE | |
| SCHEMBL2824813 | 0.82 | NOTUM (0.66) | ACE | |
| SCHEMBL2830596 | 0.82 | NOTUM (0.66) | ACE | |
| SCHEMBL31207052 | 0.82 | NOTUM (0.66) | ACE | |
| SCHEMBL29697839 | 0.82 | NOTUM (0.66) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109251163-B | Resolution method of indoline-2-formic acid compound and intermediate thereof | 江苏永达药业有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-109251163-A | A kind of method for splitting of indoline -2- formic acid compound and wherein mesosome | 江苏永达药业有限公司 | 2019-01-22 | — | — | CN | disclosed |
| US-8410130-B2 | Synthesis of 8H-3A-aza-cyclopenta [A ]indenes and 5,10-dihydropyrrolo[1,2-B]isoquinolines derivatives and their use as antitumor therapeutic agents | ACADEMIA SINICA (TW) | 2013-04-02 | — | — | US | disclosed |
| US-20090117125-A1 | SYNTHESIS OF 8H-3A-AZA-CYCLOPENTA[A]INDENES AND 5,10-DIHYDROPYRROLO[1,2-B]ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS | MEMORIAL SLOAN KETTERING CANCER CENTER | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090117125-A1 | SYNTHESIS OF 8H-3A-AZA-CYCLOPENTA[A]INDENES AND 5,10-DIHYDROPYRROLO[1,2-B]ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS | TOP2B, TOP2A, TOP1 | LMNA 2701/4885ACE 4318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.