Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 4/20 | 0.67 |
| ▸ | ADORA2A known ✓ | P29274 | 2/20 | 0.67 |
| ▸ | ADORA2B known ✓ | P29275 | 2/20 | 0.67 |
| ▸ | ADORA1 known ✓ | P30542 | 2/20 | 0.67 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.67 |
| ▸ | DPP4 | P27487 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.67 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.67 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.67 |
| ▸ | GAPDH | P04406 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 1/20 | 0.67 |
| ▸ | PI4KA | P42356 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.67 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.67 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.67 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL9736217 | 0.94 | ADORA3 (0.59) | ADORA3DOT1LADORA2AADORA2BADORA1 | |
| Guanosine SCHEMBL9138595 | 0.90 | HPGD (0.60) | ADORA3DOT1LADORA2AADORA2BADORA1 | |
| Guanosine SCHEMBL8995758 | 0.90 | HPGD (0.64) | ADORA2AADORA2BHPGD | |
| Guanosine SCHEMBL7722707 | 0.89 | ADORA3 (0.75) | ADORA3DOT1LADORA2AADORA2BADORA1 | |
| Guanosine SCHEMBL531212 | 0.89 | ADORA3 (0.75) | ADORA3DOT1LADORA2AADORA2BADORA1 | |
| Guanosine SCHEMBL6856847 | 0.89 | ADORA3 (0.75) | ADORA3DOT1LADORA2AADORA2BADORA1 | |
| Adenosine SCHEMBL21854748 | 0.88 | ADORA3 (0.52) | ADORA3DOT1LADORA2AADORA2BADORA1 | |
| Adenosine SCHEMBL3429274 | 0.87 | ADORA3 (0.66) | ADORA3DOT1LADORA2AADORA2BADORA1 | |
| Adenosine SCHEMBL536558 | 0.87 | ADORA3 (0.81) | ADORA3DOT1LADORA2AADORA2BADORA1 | |
| Vidarabine SCHEMBL27371675 | 0.87 | ADORA3 (0.81) | ADORA3DOT1LADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090017047-A1 | Preparation for the Prevention and Treatment of Stress Conditions as Well as Functional and Organic Disorders of the Nervous System and Metabolic Disorders | TECH EGON | 2009-01-15 | — | — | US | disclosed |