Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SLC13A5 | Q86YT5 | 6/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28485608 | 0.94 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL27874691 | 0.94 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL11571650 | 0.92 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL8113052 | 0.92 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL28476458 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNATSHRSLC13A5 | |
| SCHEMBL173250 | 0.83 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL4754324 | 0.81 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Ammonia Solution, Strong SCHEMBL8925075 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL30230091 | 0.79 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL28228935 | 0.79 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 348 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220217977-A1 | ULV FORMULATIONS WITH ENHANCED UPTAKE | BAYER AKTIENGESELLSCHAFT (DE) | 2022-07-14 | — | — | US | claimed |
| US-20220202768-A1 | DIHYDROMYRICETIN NANOEMULSION FORMULATIONS AND METHODS FOR FORMING THEM | CHEERS HEALTH, INC. (US) | 2022-06-30 | — | — | US | claimed |
| CN-114007421-A | Absorption-promoting ULV formulations | 拜耳公司 | 2022-02-01 | — | — | CN | claimed |
| WO-2020225437-A1 | ULV FORMULATIONS WITH ENHANCED UPTAKE | BAYER AKTIENGESELLSCHAFT (DE) | 2020-11-12 | — | — | WO | claimed |
| US-20200215027-A1 | DIHYDROMYRICETIN NANOEMULSION FORMULATIONS AND METHODS FOR FORMING THEM | THE TRUSTEES OF PRINCETON UNIVERSITY | 2020-07-09 | — | — | US | claimed |
| EP-2663181-B1 | AGRICULTURAL COMPOSITIONS COMPRISING OIL-IN-WATER EMULSIONS | DOW AGROSCIENCES LLC (US) | 2019-04-10 | — | — | EP | claimed |
| EP-2271212-B1 | STABILIZED OIL-IN-WATER EMULSIONS INCLUDING AGRICULTURALLY ACTIVE INGREDIENTS | DOW AGROSCIENCES LLC (US) | 2017-08-30 | — | — | EP | claimed |
| US-9433578-B2 | Stable bubbles via particle absorption by electrostatic interaction | L'OREAL (FR) | 2016-09-06 | — | — | US | claimed |
| US-9426982-B2 | Stabilized oil-in-water emulsions including agriculturally active ingredients | DOW AGROSCIENCES LLC (US) | 2016-08-30 | — | — | US | claimed |
| US-9402391-B2 | Stabilized oil-in-water emulsions including agriculturally active ingredients | DOW AGROSCIENCES LLC (US) | 2016-08-02 | — | — | US | claimed |
| US-20010036450-A1 | Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one poly ethylene glycol (PEG) ester, and uses thereof | L'OREAL S.A. (FR) | 2001-11-01 | — | — | US | claimed |
| US-20010028887-A1 | Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one cationic polymer, and uses thereof | L'OREAL S.A. (FR) | 2001-10-11 | — | — | US | claimed |
| EP-1123271-A1 | NOVEL AMINE AND QUATERNARY AMMONIUM COMPOUNDS MADE FROM KETONES AND ALDEHYDES, AND COMPOSITIONS CONTAINING THEM | Goldschmidt Chemical Company (US) | 2001-08-16 | — | — | EP | claimed |
| US-6235914-B1 | Amine and quaternary ammonium compounds made from ketones and aldehydes, and compositions containing them | GOLDSCHMIDT CHEMICAL COMPANY | 2001-05-22 | — | — | US | claimed |
| EP-1020219-B1 | Nanoemulsion based on alkylether citrates and uses thereof in the fields of cosmetics, dermatology, pharmaceuticals and/or ophthalmology | OREAL (FR) | 2001-03-21 | — | — | EP | claimed |
| WO-2001014313-A1 | NOVEL AMINE AND QUATERNARY AMMONIUM COMPOUNDS MADE FROM KETONES AND ALDEHYDES, AND COMPOSITIONS CONTAINING THEM | GOLDSCHMIDT CHEMICAL COMPANY (US) | 2001-03-01 | — | — | WO | claimed |
| EP-1045891-A1 | NOVEL QUATERNARY AMMONIUM COMPOUNDS, COMPOSITIONS CONTAINING THEM, AND USES THEREOF | Goldschmidt Chemical Corporation (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999035120-A1 | NOVEL QUATERNARY AMMONIUM COMPOUNDS, COMPOSITIONS CONTAINING THEM, AND USES THEREOF | WITCO CORPORATION (US) | 1999-07-15 | — | — | WO | claimed |
| WO-1999035223-A1 | NOVEL QUATERNARY AMMONIUM COMPOUNDS, COMPOSITIONS CONTAINING THEM, AND USES THEREOF | WITCO CORPORATION (US) | 1999-07-15 | — | — | WO | claimed |
| EP-0371339-B1 | SURFACTANT MIXTURES | Henkel Kommanditgesellschaft auf Aktien (DE) | 1993-03-03 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010028887-A1 | Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one cationic polymer, and uses thereof | LIPA, PHOSPHO1, LIPC | MEN1 593/4885ALDH1A1 4658/4885KDM4E 4685/4885 |
| US-20010036450-A1 | Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one poly ethylene glycol (PEG) ester, and uses thereof | PHOSPHO1, SGMS1, SGMS2 | MEN1 1096/4885ALDH1A1 3506/4885KDM4E 4639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.