Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 6/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | TPH1 | P17752 | 2/20 | 0.33 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4133677 | 0.91 | TPH1 (0.33) | KDM4EHCRTR1HCRTR2HTR2CATM | |
| SCHEMBL8046391 | 0.88 | KDM4E (0.35) | KDM4EHCRTR1HCRTR2ATMPIK3C3 | |
| SCHEMBL4128912 | 0.87 | PDE5A (0.41) | ALDH1A1 | |
| SCHEMBL4903686 | 0.86 | KDM4E (0.37) | KDM4EHCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL4895781 | 0.86 | KDM4E (0.38) | KDM4EHCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL8032546 | 0.85 | HCRTR1 (0.37) | KDM4EHCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL4893446 | 0.84 | KDM4E (0.37) | KDM4EALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL4903611 | 0.83 | KDM4E (0.36) | KDM4EALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL4123059 | 0.81 | PDE5A (0.34) | HCRTR1HCRTR2HTR2CATMPIK3C3 | |
| SCHEMBL4117755 | 0.80 | KDM4E (0.41) | KDM4EALDH1A1MAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |