Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 8/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128842 | 0.88 | KDM4E (0.35) | KDM4ENPSR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4117755 | 0.80 | KDM4E (0.41) | KDM4ENPSR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4133677 | 0.79 | TPH1 (0.33) | KDM4EALDH1A1MAPTHTTATM | |
| SCHEMBL4123024 | 0.78 | ALDH1A1 (0.36) | KDM4ENPSR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8045132 | 0.78 | KDM4E (0.41) | KDM4ENPSR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4131082 | 0.76 | MAPT (0.34) | KDM4ENPSR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8032546 | 0.75 | HCRTR1 (0.37) | KDM4ENPSR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8034133 | 0.75 | KDM4E (0.36) | KDM4ENPSR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3995952 | 0.75 | KDM4E (0.39) | KDM4ENPSR1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4128912 | 0.74 | PDE5A (0.41) | ALDH1A1PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |