Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FADS1 | O60427 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | RRM1 | P23921 | 1/20 | 0.32 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4116943 | 0.85 | SCN9A (0.37) | CYP3A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| SCHEMBL4119367 | 0.83 | CYP3A4 (0.37) | CYP3A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| SCHEMBL4125270 | 0.83 | LPAR1 (0.38) | ALDH1A1TDP1KMT2AL3MBTL1MAPT | |
| SCHEMBL14378000 | 0.80 | CYP3A4 (0.43) | CYP3A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| SCHEMBL4117586 | 0.78 | CYP3A4 (0.43) | CYP3A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| SCHEMBL18287878 | 0.78 | TRPA1 (0.48) | CYP3A4ALDH1A1TSHRSMN1; SMN2HPGD | |
| SCHEMBL3255465 | 0.78 | RECQL (0.46) | CYP3A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| SCHEMBL19939484 | 0.78 | CYP3A4 (0.41) | CYP3A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| SCHEMBL14146247 | 0.77 | KIF11 (0.42) | CYP3A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| SCHEMBL4121986 | 0.76 | ADRA2A (0.42) | CYP3A4ALDH1A1TSHRALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | CYP3A4 1692/4885ALDH1A1 1587/4885TSHR 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.