Sugi Predict

Sugi Predict / Compounds / SCHEMBL4119141

SCHEMBL4119141

SCHEMBL4119141

CCOC(=O)c1ccc2[nH]c(-c3ccccc3)cc(=O)c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB4A P04350 2/20 1.00
▸ TUBB P07437 2/20 1.00
▸ TUBA3C P0DPH7 2/20 1.00
▸ TUBA1B P68363 2/20 1.00
▸ TUBA4A P68366 2/20 1.00
▸ TUBB4B P68371 2/20 1.00
▸ TUBB3 Q13509 2/20 1.00
▸ TUBB2A Q13885 2/20 1.00
▸ TUBB8 Q3ZCM7 2/20 1.00
▸ TUBA3E Q6PEY2 2/20 1.00
▸ TUBA1A Q71U36 2/20 1.00
▸ TUBA1C Q9BQE3 2/20 1.00
▸ TUBB6 Q9BUF5 2/20 1.00
▸ TUBB2B Q9BVA1 2/20 1.00
▸ TUBB1 Q9H4B7 2/20 1.00
▸ KDM4E B2RXH2 9/20 0.72
▸ MAPT P10636 6/20 0.72
▸ ALDH1A1 P00352 7/20 0.69
▸ HPGD P15428 7/20 0.69
▸ HSD17B10 Q99714 6/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22552082 0.94 TUBB4A (0.89) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29902959 0.94 TUBB4A (0.89) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29902937 0.90 TUBB4A (0.82) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL22552128 0.90 TUBB4A (0.82) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29902940 0.89 TUBB4A (0.80) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL22552099 0.89 TUBB4A (0.80) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL22552130 0.89 TUBB4A (0.79) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL22552113 0.88 TUBB4A (0.79) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL22552107 0.88 TUBB4A (0.79) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29903038 0.88 TUBB4A (0.79) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12109207-B2 Methods of using 4(1H)-quinolone derivatives ACADEMIA SINICA (TW) 2024-10-08 — — US disclosed
US-20230233549-A1 METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES ACADEMIA SINICA (TW) 2023-07-27 — — US disclosed
US-20230233549-A1 METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES ACADEMIA SINICA (TW) 2023-07-27 — — US disclosed
US-20230233549-A1 METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES ACADEMIA SINICA (TW) 2023-07-27 — — US disclosed
US-11638705-B2 4(1H)-quinolone derivatives and uses thereof ACADEMIA SINICA (TW) 2023-05-02 — — US disclosed
US-11638705-B2 4(1H)-quinolone derivatives and uses thereof ACADEMIA SINICA (TW) 2023-05-02 — — US disclosed
US-11638705-B2 4(1H)-quinolone derivatives and uses thereof ACADEMIA SINICA (TW) 2023-05-02 — — US disclosed
CN-111825611-B 4(1H) -quinovone derivatives and uses thereof 刘扶东 2022-09-09 — — CN disclosed
CN-111825611-A 4(1H) -quinovone derivatives and uses thereof 中央研究院 2020-10-27 — — CN disclosed
US-20200330449-A1 4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF ACADEMIA SINICA (TW) 2020-10-22 — — US disclosed
US-20200330449-A1 4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF ACADEMIA SINICA (TW) 2020-10-22 — — US disclosed
US-7511145-B2 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. (US) 2009-03-31 — — US disclosed
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES GENELABS TECHNOLOGIES, INC. 2009-03-26 — — US disclosed
EP-1651631-A1 BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE GENELABS TECHNOLOGIES, INC. (US) 2006-05-03 — — EP disclosed
US-20050187390-A1 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. 2005-08-25 — — US disclosed
WO-2005012288-A1 BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE GENELABS TECHNOLOGIES, INC (US) 2005-02-10 — — WO disclosed
US-4711898-A 4-quinolone derivatives having anti-inflammatory, anti-allergic, antitussive, expectorant and antithrombotic activity NIPPON SHINYAKU CO., LTD. (JP) 1987-12-08 — — US disclosed
EP-0104959-B1 4-QUINOLONE DERIVATIVES NIPPON SHINYAKU COMPANY, LIMITED (JP) 1987-01-21 — — EP disclosed
EP-0104959-A1 4-Quinolone derivatives NIPPON SHINYAKU COMPANY, LIMITED (JP) 1984-04-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11638705-B2 4(1H)-quinolone derivatives and uses thereof TUBB1, TUBB3, TUBB TUBB4A 5/4885TUBB 3/4885TUBA3C 19/4885
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES HAVCR2, MAVS, ZC3HAV1 TUBB4A 1892/4885TUBB 2008/4885TUBA3C 433/4885
US-12109207-B2 Methods of using 4(1H)-quinolone derivatives TUBB1, TUBB3, TUBB TUBB4A 6/4885TUBB 3/4885TUBA3C 20/4885
US-20200330449-A1 4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF TUBB1, TUBB3, TUBA1C TUBB4A 5/4885TUBB 4/4885TUBA3C 18/4885
US-20050187390-A1 Bicyclic heteroaryl derivatives HAVCR2, MAVS, ZC3HAV1 TUBB4A 1892/4885TUBB 2008/4885TUBA3C 433/4885
US-20230233549-A1 METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES TUBB1, TUBB3, TUBB TUBB4A 6/4885TUBB 3/4885TUBA3C 20/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.