Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | F13A1 | P00488 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | TGM1 | P22735 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13768041 | 0.87 | HSD11B1 (0.38) | HSD11B1GPR119NR1H2NR1H3HDAC1 | |
| SCHEMBL13767982 | 0.84 | CHRNB4 (0.40) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13768190 | 0.84 | AR (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3GPR119 | |
| SCHEMBL13768179 | 0.83 | CHRNB4 (0.48) | HSD11B1CHRNB4CHRNA3USP30GPR119 | |
| SCHEMBL2949364 | 0.83 | GPR119 (0.48) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL11963191 | 0.83 | GPR119 (0.48) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13768040 | 0.83 | HDAC1 (0.38) | HSD11B1CHRNB4CHRNA3GPR119NR1H2 | |
| SCHEMBL13768039 | 0.83 | CHRNB2 (0.39) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13768188 | 0.81 | HTT (0.39) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4120182 | 0.80 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197860-A1 | BIARYL SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-08-06 | — | — | US | disclosed |
| WO-2009081246-A2 | BICYCLIC DIAMINES AS NICOTINIC RECEPTOR AGONISTS | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197860-A1 | BIARYL SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES | BRCA1, VHL, AADAC | HSD11B1 177/4885CHRNB2 3338/4885CHRNA4 3801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.