Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 8/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13768041 | 0.84 | HSD11B1 (0.38) | HDAC1HSD11B1NR1H2NR1H3 | |
| SCHEMBL13768188 | 0.84 | HTT (0.39) | CHRNB4CHRNA3CHRNB2CHRNA4HDAC1 | |
| SCHEMBL4119940 | 0.84 | HSD11B1 (0.39) | CHRNB4CHRNA3CHRNB2CHRNA4UCHL1 | |
| SCHEMBL13768190 | 0.82 | AR (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL13768179 | 0.81 | CHRNB4 (0.48) | CHRNB4CHRNA3USP30HDAC1HSD11B1 | |
| SCHEMBL13768039 | 0.80 | CHRNB2 (0.39) | CHRNB4CHRNA3CHRNB2CHRNA4HDAC1 | |
| SCHEMBL13768040 | 0.79 | HDAC1 (0.38) | CHRNB4CHRNA3HDAC1HSD11B1NR1H2 | |
| SCHEMBL13768184 | 0.77 | GPR119 (0.35) | CHRNB4CHRNA3HDAC1HSD11B1NR1H2 | |
| SCHEMBL23572659 | 0.76 | GPR119 (0.48) | ATMNR1H2 | |
| SCHEMBL25614203 | 0.75 | CHRNB4 (0.50) | CHRNB4CHRNA3CHRNB2CHRNA4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081246-A2 | BICYCLIC DIAMINES AS NICOTINIC RECEPTOR AGONISTS | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |