Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.51 |
| ▸ | MTOR | P42345 | 4/20 | 0.51 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.49 |
| ▸ | ADK | P55263 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | AKT1 | P31749 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4117117 | 0.90 | HTR1A (0.47) | PIK3CAMTORADKHTR1AAKT1 | |
| SCHEMBL13848253 | 0.84 | ADK (0.57) | PIK3CAMTORMAP3K12ADKHTR1A | |
| SCHEMBL3990409 | 0.82 | PIK3CA (0.58) | PIK3CAMTORMAP3K12AKT1PIK3CB | |
| SCHEMBL3997060 | 0.80 | PIK3CA (0.59) | PIK3CAMTORMAP3K12AKT1PIK3CB | |
| SCHEMBL13848126 | 0.78 | PIK3CA (0.56) | PIK3CAMTORMAP3K12AKT1PIK3CB | |
| SCHEMBL13848119 | 0.78 | PIK3CA (0.53) | PIK3CAMTORMAP3K12AKT1PIK3CB | |
| SCHEMBL13848198 | 0.77 | PIK3CA (0.60) | PIK3CAMTORMAP3K12AKT1PIK3CB | |
| SCHEMBL10327867 | 0.76 | PIK3CA (0.61) | PIK3CAMTORMAP3K12PIK3CBPIK3CD | |
| SCHEMBL3990236 | 0.75 | PIK3CA (0.51) | PIK3CAMTORMAP3K12AKT1PIK3CB | |
| SCHEMBL4125340 | 0.75 | PIK3CA (0.60) | PIK3CAMTORMAP3K12PIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |