Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.36 |
| ▸ | MIF | P14174 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL439920 | 0.98 | HDAC6 (0.35) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL13189194 | 0.85 | MIF (0.35) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL3713070 | 0.84 | MIF (0.34) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL21824501 | 0.80 | HDAC6 (0.43) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL8233965 | 0.80 | HDAC4 (0.39) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL2308502 | 0.80 | MIF (0.34) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL21634141 | 0.80 | HDAC6 (0.34) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL8761464 | 0.80 | MIF (0.34) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL989859 | 0.78 | HDAC6 (0.34) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL20365263 | 0.77 | AOC3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11737463-B2 | Pyridine and pyrazine compounds | BASF SE (DE) | 2023-08-29 | — | — | US | disclosed |
| WO-2022164239-A1 | PYRAZOLE-CARBOXAMIDE DERIVATIVE COMPOUND AND USE THEREOF | 주식회사 파미노젠 | 2022-08-04 | — | — | WO | disclosed |
| US-20210145002-A1 | PYRIDINE AND PYRAZINE COMPOUNDS | BASF SE (DE) | 2021-05-20 | — | — | US | disclosed |
| US-20200354321-A1 | NEW PYRIDINE CARBOXAMIDES | BASF SE (DE) | 2020-11-12 | — | — | US | disclosed |
| US-10696634-B2 | Pyridine compounds as fungicides | BASF SE (DE) | 2020-06-30 | — | — | US | disclosed |
| US-20200187500-A1 | PYRIDINE COMPOUNDS | BASF SE (DE) | 2020-06-18 | — | — | US | disclosed |
| EP-2613785-B1 | HETEROARYLMETHYL AMIDES | HOFFMANN LA ROCHE (CH) | 2015-07-29 | — | — | EP | disclosed |
| US-9090599-B2 | Heteroarylmethyl amides | HOFFMANN-LA ROCHE INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-9090599-B2 | Heteroarylmethyl amides | HOFFMANN-LA ROCHE INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-20140194436-A1 | HETEROARYLMETHYL AMIDES | HOFFMANN-LA ROCHE INC. (US) | 2014-07-10 | — | — | US | disclosed |
| US-20140194436-A1 | HETEROARYLMETHYL AMIDES | HOFFMANN-LA ROCHE INC. (US) | 2014-07-10 | — | — | US | disclosed |
| US-8729105-B2 | Heteroarylmethyl amides | HOFFMANN LA-ROCHE INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8729105-B2 | Heteroarylmethyl amides | HOFFMANN LA-ROCHE INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20120065212-A1 | HETEROARYLMETHYL AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | US | disclosed |
| US-20120065212-A1 | HETEROARYLMETHYL AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | US | disclosed |
| WO-2012032018-A1 | HETEROARYLMETHYL AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194436-A1 | HETEROARYLMETHYL AMIDES | APOB, LDLR, HMGCR | HDAC6 936/4885HDAC4 1414/4885MIF 4292/4885 |
| US-11737463-B2 | Pyridine and pyrazine compounds | NDUFS5, IL5, NDUFS4 | HDAC6 2170/4885HDAC4 2046/4885MIF 3156/4885 |
| US-20210145002-A1 | PYRIDINE AND PYRAZINE COMPOUNDS | NDUFS5, IL5, NDUFS4 | HDAC6 2170/4885HDAC4 2046/4885MIF 3156/4885 |
| US-20200354321-A1 | NEW PYRIDINE CARBOXAMIDES | COX4I1, NQO2, NDUFS5 | HDAC6 399/4885HDAC4 582/4885MIF 4367/4885 |
| US-10696634-B2 | Pyridine compounds as fungicides | CYP4X1, CYP1A1, CYP4B1 | HDAC6 1525/4885HDAC4 1201/4885MIF 3087/4885 |
| US-20200187500-A1 | PYRIDINE COMPOUNDS | NQO1, NDUFS5, NDUFS4 | HDAC6 2209/4885HDAC4 2649/4885MIF 3626/4885 |
| US-20120065212-A1 | HETEROARYLMETHYL AMIDES | APOB, LDLR, HMGCR | HDAC6 936/4885HDAC4 1414/4885MIF 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.