Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.34 |
| ▸ | MIF | P14174 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24452460 | 0.91 | HDAC4 (0.41) | HDAC6HDAC4MIF | |
| SCHEMBL20680138 | 0.89 | CHRM2 (0.39) | HDAC6HDAC4HDAC1HDAC8NR1I2 | |
| SCHEMBL20469590 | 0.84 | PPARA (0.38) | HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL24259652 | 0.84 | HDAC4 (0.32) | HDAC6HDAC4MIFHDAC1 | |
| SCHEMBL2222989 | 0.82 | ALDH1A1 (0.40) | HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL13838829 | 0.82 | HDAC4 (0.33) | HDAC6HDAC4MIFHDAC1 | |
| SCHEMBL22858812 | 0.82 | ALDH1A1 (0.41) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL13189194 | 0.82 | MIF (0.35) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| SCHEMBL9126570 | 0.82 | MIF (0.33) | HDAC6HDAC4MIFHDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL3713070 | 0.80 | MIF (0.34) | HDAC6HDAC4MIFHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012985-B2 | parasiticides, in particularly against Plasmodium and babesia; antimalarial agents | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2011-09-06 | — | — | US | disclosed |
| EP-2275100-A2 | Compounds with anti-parasitic activity and drugs containing said compounds | Centre National de la Recherche Scientifique (CNRS) (FR) | 2011-01-19 | — | — | EP | disclosed |
| EP-2266555-A2 | Compounds with antiparasitic activity and medicines containing same | Centre National de la Recherche Scientifique (CNRS) (FR) | 2010-12-29 | — | — | EP | disclosed |
| EP-2260840-A2 | Compounds with antiparasitic activity and medicines containing same | Centre National de la Recherche Scientifique (CNRS) (FR) | 2010-12-15 | — | — | EP | disclosed |
| EP-2260841-A2 | Compounds with antiparasitic activity and medicines containing same | Centre National de la Recherche Scientifique (CNRS) (FR) | 2010-12-15 | — | — | EP | disclosed |
| US-20050176819-A1 | Compounds with antiparasitic activity and medicines containing same | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N. (FR) | 2005-08-11 | — | — | US | disclosed |
| EP-1524972-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY AND MEDICINES CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004009068-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY AND MEDICINES CONTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176819-A1 | Compounds with antiparasitic activity and medicines containing same | ACHE, MPO, PDF | HDAC6 634/4885HDAC4 2387/4885MIF 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.