NDUFS4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20
SCHEMBL6267768	0.55	3/20
SCHEMBL1095981	0.55	3/20
SCHEMBL4293165	0.55	3/20
SCHEMBL8490928	0.53	3/20
SCHEMBL8490937	0.53	3/20

Clinical trials — most relevant to NDUFS4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling	nan	ACTIVE_NOT_RECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
EPI-743 for Mitochondrial Respiratory Chain Diseases	nan	NO_LONGER_AVAILABLE
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis	nan	UNKNOWN
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a NDUFS4 binder may also engage these)

Protein	Name	Similarity
Q0MQH0	—	1.000	Q0MQH0 →
Q0MQH1	—	1.000	Q0MQH1 →
P0CB96	—	1.000	P0CB96 →
P0CB95	—	1.000	P0CB95 →
Q9CXZ1	—	0.999	Q9CXZ1 →
Q02375	—	0.998	Q02375 →
Q66XS7	—	0.990	Q66XS7 →
Q5XIF3	—	0.990	Q5XIF3 →
Q5U2U0	—	0.941	Q5U2U0 →
MCU	Calcium uniporter protein, mitochondrial	0.941	landscape →
Q1LZ96	—	0.939	Q1LZ96 →
Q3UMR5	—	0.938	Q3UMR5 →
Q91YY4	—	0.937	Q91YY4 →
Q9JHS4	—	0.936	Q9JHS4 →
Q9Y2S7	—	0.936	Q9Y2S7 →
Q8K1Z0	—	0.936	Q8K1Z0 →
P11029	—	0.935	P11029 →
P11497	—	0.935	P11497 →
Q91VA6	—	0.934	Q91VA6 →
A3KN28	—	0.934	A3KN28 →
Q5SWU9	—	0.934	Q5SWU9 →
P82670	—	0.934	P82670 →
Q5R7N3	—	0.933	Q5R7N3 →
Q28559	—	0.933	Q28559 →
ACACA	Acetyl-CoA carboxylase 1	0.933	landscape →
Q80ZK0	—	0.933	Q80ZK0 →
Q9TTS3	—	0.933	Q9TTS3 →
Q8N5M1	—	0.933	Q8N5M1 →
Q6P6Q9	—	0.933	Q6P6Q9 →
Q93V56	—	0.933	Q93V56 →