Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4110516 | 0.83 | ADORA2A (0.43) | GRM5ADORA2AADORA1TGFBR1CLK4 | |
| SCHEMBL5203671 | 0.82 | MAPK14 (0.48) | TGFBR1CYP1A2CYP2C19CYP3A4ALOX15 | |
| SCHEMBL4102560 | 0.78 | ADORA3 (0.63) | GRM5ADORA2BADORA2AADORA1CLK4 | |
| SCHEMBL18889616 | 0.78 | GRM5 (0.83) | GRM5ADORA2BCLK4CYP1A2CYP2C19 | |
| SCHEMBL25365761 | 0.78 | MAP4K4 (0.46) | GRM5ADORA2AADORA1TGFBR1CLK4 | |
| SCHEMBL30520106 | 0.78 | MAP4K4 (0.46) | GRM5ADORA2AADORA1TGFBR1CLK4 | |
| SCHEMBL4103774 | 0.76 | ADORA2A (0.45) | ADORA2BADORA2AADORA1TGFBR1CLK4 | |
| SCHEMBL24227925 | 0.76 | ADORA2A (0.47) | ADORA2BADORA2AADORA1TGFBR1CLK4 | |
| SCHEMBL30552536 | 0.76 | ADORA2A (0.47) | ADORA2BADORA2AADORA1TGFBR1CLK4 | |
| SCHEMBL29381457 | 0.76 | MAPT (0.50) | ADORA2BADORA2AADORA1TGFBR1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233938-A1 | Thiazole derivatives as a2b antagonists | NOVARTIS AG (CH) | 2009-09-17 | — | — | US | disclosed |
| EP-1709036-B1 | THIAZOLE DERIVATIVES AS A2B ANTAGONISTS | NOVARTIS AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| EP-1709036-A1 | THIAZOLE DERIVATIVES AS A2B ANTAGONISTS | Novartis AG (CH) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070926-A1 | THIAZOLE DERIVATIVES AS A2B ANTAGONISTS | NOVARTIS AG (CH) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233938-A1 | Thiazole derivatives as a2b antagonists | ADORA2B, ADRA2B, AGTR2 | GRM5 1915/4885ADORA2B 1/4885ADORA2A 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.