Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256708 | 0.85 | CCR5 (0.48) | CCR5SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL4115232 | 0.81 | SLC6A4 (0.45) | SLC6A2SLC6A4ALDH1A1KDM4EMEN1 | |
| SCHEMBL30673419 | 0.80 | KDM4E (0.42) | ALDH1A1AAK1KDM4EPOLBMEN1 | |
| SCHEMBL560494 | 0.80 | KDM4E (0.42) | ALDH1A1AAK1KDM4EPOLBMEN1 | |
| SCHEMBL16429762 | 0.79 | USP28 (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2CXCR4 | |
| SCHEMBL4437659 | 0.79 | EDNRB (0.37) | ALDH1A1KDM4EPOLBCTDSP1MEN1 | |
| SCHEMBL18685094 | 0.78 | CCR5 (0.51) | CCR5SLC6A4ALDH1A1KDM4EPOLB | |
| SCHEMBL31155264 | 0.76 | KDM4E (0.42) | ALDH1A1AAK1KDM4EPOLBMEN1 | |
| SCHEMBL134773 | 0.74 | CCR5 (0.48) | CCR5ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL26985827 | 0.74 | CCR5 (0.51) | CCR5ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168644-B2 | Quinazolinone derivatives as tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-01 | — | — | US | disclosed |
| US-8168644-B2 | Quinazolinone derivatives as tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-01 | — | — | US | disclosed |
| US-20110028433-A1 | QUINAZOLINONE DERIVATIVES AS TUBULIN POLYMERIZATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-03 | — | — | US | disclosed |
| US-20110028433-A1 | QUINAZOLINONE DERIVATIVES AS TUBULIN POLYMERIZATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028433-A1 | QUINAZOLINONE DERIVATIVES AS TUBULIN POLYMERIZATION INHIBITORS | TUBB3, TUBB1, TUBA1C | CCR5 3769/4885SLC6A2 3084/4885SLC6A4 3524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.