Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 4/20 | 0.49 |
| ▸ | USP25 | Q9UHP3 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6338288 | 0.82 | MAPK1 (0.38) | USP28USP25MAPK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6339523 | 0.81 | ALDH1A1 (0.41) | USP28USP25MAPK1HTTSMN1; SMN2 | |
| SCHEMBL31575955 | 0.81 | USP28 (0.51) | USP28USP25MAPK1HTTSMN1; SMN2 | |
| SCHEMBL4123546 | 0.79 | CCR5 (0.44) | SMN1; SMN2MEN1KMT2AALDH1A1CA12 | |
| SCHEMBL31155264 | 0.77 | KDM4E (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL2540684 | 0.76 | KDM4E (0.38) | MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL754025 | 0.75 | KDM4E (0.41) | MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL4115232 | 0.74 | SLC6A4 (0.45) | MEN1KMT2AALDH1A1 | |
| SCHEMBL3594118 | 0.73 | GAA (0.49) | HTTMEN1KMT2AALDH1A1CA12 | |
| SCHEMBL27654704 | 0.72 | ALDH1A1 (0.42) | KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027601-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2016-06-08 | — | — | EP | disclosed |
| WO-2015017610-A1 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-02-05 | — | — | WO | disclosed |