Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
| ▸ | SLC16A1 | P53985 | 13/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29959844 | 1.00 | POLB (0.64) | POLBADORA2AADORA2BADORA1SLC16A1 | |
| SCHEMBL13938656 | 1.00 | POLB (0.64) | POLBADORA2AADORA2BADORA1SLC16A1 | |
| SCHEMBL4123656 | 1.00 | POLB (0.64) | POLBADORA2AADORA2BADORA1SLC16A1 | |
| SCHEMBL14603500 | 0.85 | POLB (0.47) | POLBADORA2AADORA2BADORA1SLC16A1 | |
| SCHEMBL4660049 | 0.85 | POLB (0.47) | POLBADORA2AADORA2BADORA1SLC16A1 | |
| SCHEMBL10521426 | 0.85 | ALDH1A1 (0.66) | POLBKDM4EKMT2ALMNAMEN1 | |
| SCHEMBL4662622 | 0.85 | ALDH1A1 (0.66) | POLBKDM4EKMT2ALMNAMEN1 | |
| SCHEMBL4660043 | 0.85 | POLB (0.47) | POLBADORA2AADORA2BADORA1SLC16A1 | |
| SCHEMBL4662620 | 0.85 | ALDH1A1 (0.66) | POLBKDM4EKMT2ALMNAMEN1 | |
| SCHEMBL4661306 | 0.83 | CRHBP (0.60) | SLC16A1KDM4EKMT2ALMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476752-B2 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters | WYETH (US) | 2009-01-13 | — | — | US | disclosed |
| WO-2005123663-A1 | PROCESSES FOR THE PREPARATION OF 2-CYANO-3-NAPHTHALENE-1-YL-3-PHENYL-PROPIONIC ACID ALKYL OR BENZYL ESTERS | WYETH (US) | 2005-12-29 | — | — | WO | disclosed |
| US-20050277783-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters | WYETH (US) | 2005-12-15 | — | — | US | disclosed |
| US-20050277784-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-acrylic acid alkyl or benzyl esters | WYETH (US) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277783-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters | PCCA, PAH, CYP7A1 | POLB 2400/4885ADORA2A 3110/4885ADORA2B 2250/4885 |
| US-20050277784-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-acrylic acid alkyl or benzyl esters | TNF, ACACA, PCCA | POLB 1874/4885ADORA2A 2736/4885ADORA2B 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.