Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 7/20 | 1.00 |
| ▸ | DHFR | P00374 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | TTR | P02766 | 1/20 | 0.69 |
| ▸ | ALB | P02768 | 1/20 | 0.69 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.67 |
| ▸ | HNF4A | P41235 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17202660 | 0.88 | MCL1 (0.77) | ACMSDDHFRKDM4EMEN1USP2 | |
| SCHEMBL4428964 | 0.87 | ACMSD (0.77) | ACMSDDHFRKDM4EMEN1USP2 | |
| SCHEMBL28173338 | 0.87 | ACMSD (0.77) | ACMSDDHFRKDM4EMEN1USP2 | |
| SCHEMBL18742254 | 0.86 | ACMSD (0.76) | ACMSDDHFRKDM4EMEN1USP2 | |
| SCHEMBL14252244 | 0.86 | ACMSD (0.76) | ACMSDDHFRKDM4EMEN1USP2 | |
| SCHEMBL29360995 | 0.86 | ACMSD (0.76) | ACMSDDHFRKDM4EMEN1USP2 | |
| SCHEMBL2533617 | 0.84 | ACMSD (0.76) | ACMSDDHFRKDM4EMEN1USP2 | |
| SCHEMBL505872 | 0.83 | ACMSD (0.71) | ACMSDDHFRKDM4EMEN1USP2 | |
| Diflunisal SCHEMBL6277460 | 0.82 | ACMSD (0.86) | ACMSDDHFRKDM4EMEN1USP2 | |
| Diflunisal SCHEMBL29367380 | 0.82 | ACMSD (1.00) | ACMSDDHFRKDM4EMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101888776-A | Method and compositions for treatment or prevention of inflammatory conditions | UNIV ROCHESTER | 2010-11-17 | — | — | CN | claimed |
| CN-101175720-A | Novel haloalkyl sulfone substituted compounds useful for the treatment of obesity and diabetes | NOVO NORDISK AS (DK) | 2008-05-07 | — | — | CN | claimed |
| CN-110201180-A | The medicinal nanoemulsions preparation in the part of liquid | JRX生物技术有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-105209011-B | Liquid topical pharmaceutical nanoemulsion formulations | JRX生物技术有限公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-108578376-A | The sustained release pellet composition of performance improvement | 广州柏赛罗药业有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-108295262-A | The pharmaceutical composition containing anti-inflammatory agent and antioxidant conjugate for treating dysbolism | 根梅迪卡治疗公司 | 2018-07-20 | — | — | CN | disclosed |
| CN-103945839-B | Pharmaceutical combination comprising an anti-inflammatory agent and an antioxidant conjugate for the treatment of metabolic disorders | 根梅迪卡治疗公司 | 2018-02-09 | — | — | CN | disclosed |
| CN-105209011-A | Liquid topical pharmaceutical nanoemulsion formulations | JRX BIOTECHNOLOGY INC | 2015-12-30 | — | — | CN | disclosed |
| CN-101888776-B | Method and compositions for treatment or prevention of inflammatory conditions | UNIV ROCHESTER | 2015-03-11 | — | — | CN | disclosed |
| EP-2325651-B1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST (US) | 2014-10-08 | — | — | EP | disclosed |
| EP-2325651-B1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST (US) | 2014-10-08 | — | — | EP | disclosed |
| WO-2005058230-A2 | TOPICAL USE OF HALOSALICYLIC ACID DERIVATIVES | AVON PRODUCTS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |
| US-20050136015-A1 | Topical use of halosalicylic acid derivatives | AVON PRODUCTS, INC. | 2005-06-23 | — | — | US | disclosed |
| US-20040152140-A1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | THE SCRIPPS RESEARCH INSTITUTE | 2004-08-05 | — | — | US | disclosed |
| WO-2004056315-A2 | COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-07-08 | — | — | WO | disclosed |
| EP-0017169-A1 | Improved anti-inflammatory combinations having reduced ulcerogenicity | MERCK & CO. INC. (US) | 1980-10-15 | — | — | EP | disclosed |
| EP-0017102-A1 | Composition containing a phenyl benzoic acid compound and acetaminophen combination for the treatment of pain and inflammation and process for preparing the same | MERCK & CO. INC. (US) | 1980-10-15 | — | — | EP | disclosed |
| US-4228161-A | INDOMETHACIN AND A SUBSTITUTED PHENYL BENZOIC ACID | MERCK & CO., INC. (US) | 1980-10-14 | — | — | US | disclosed |
| US-4217340-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. (US) | 1980-08-12 | — | — | US | disclosed |
| US-4044049-A | Phenyl benzoic acid compounds | MERCK & CO., INC. (US) | 1977-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050136015-A1 | Topical use of halosalicylic acid derivatives | NACA, TYR, PRKDC | ACMSD 1718/4885DHFR 2300/4885KDM4E 2989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.