Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 6/20 | 0.50 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410495 | 0.83 | CHKA (0.42) | CHKAHTR6MC4RKMT2AKDM4E | |
| Fumaric Acid SCHEMBL2704443 | 0.76 | HTR7 (0.42) | HTR6MC4RKMT2AKDM4EMEN1 | |
| Fumaric Acid SCHEMBL2704445 | 0.76 | HTR7 (0.42) | HTR6MC4RKMT2AKDM4EMEN1 | |
| SCHEMBL412750 | 0.74 | CHRNB1 (0.49) | CHKAMC4RKMT2A | |
| SCHEMBL412721 | 0.74 | DRD4 (0.44) | CHKAHTR6KMT2A | |
| SCHEMBL12891510 | 0.73 | ALDH1A1 (0.69) | CHKAMC4RKDM4EALDH1A1MAPT | |
| SCHEMBL13499599 | 0.72 | CHKA (0.88) | CHKAMC4RKMT2AMEN1PKM | |
| SCHEMBL10071720 | 0.70 | CHKA (0.56) | CHKAMC4RKDM4EALDH1A1 | |
| SCHEMBL414890 | 0.69 | KDM4E (0.68) | CHKAHTR6MC4RKDM4EALDH1A1 | |
| SCHEMBL29468844 | 0.69 | KDM4E (0.68) | CHKAHTR6MC4RKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448921-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-05-09 | — | — | EP | claimed |
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-01-26 | — | — | US | claimed |
| WO-2010117085-A1 | ARYL INDOLE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-10-14 | — | — | WO | claimed |
| EP-2448921-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-05-09 | — | — | EP | disclosed |
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-01-26 | — | — | US | disclosed |
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-01-26 | — | — | US | disclosed |
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-01-26 | — | — | US | disclosed |
| WO-2010117085-A1 | ARYL INDOLE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010117085-A1 | ARYL INDOLE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | IDO1, NAT1, IDO2 | CHKA 2500/4885HTR6 63/4885MC4R 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.