Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB1 | P11230 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | CHKA | P35790 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 6/20 | 0.44 |
| ▸ | DRD3 | P35462 | 6/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606405 | 0.85 | GSK3B (0.44) | CYP11B2MC4RCHKADRD4DRD3 | |
| SCHEMBL1605878 | 0.81 | KMT2A (0.55) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL1606591 | 0.80 | KMT2A (0.54) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL7679008 | 0.79 | DRD2 (0.61) | MC4RCHKADRD4DRD3DRD2 | |
| SCHEMBL410495 | 0.78 | CHKA (0.42) | KMT2ACYP11B2MC4RCHKADRD4 | |
| SCHEMBL1606281 | 0.78 | PABPC1 (0.49) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL28106936 | 0.77 | CYP11B2 (0.45) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL1606261 | 0.76 | CHRNB1 (0.51) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL1605531 | 0.74 | CYP11B2 (0.69) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL1605594 | 0.74 | PRMT6 (0.45) | KMT2ACYP11B2GSK3BDYRK1ADCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-01-26 | — | — | US | claimed |
| EP-2448921-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-05-09 | — | — | EP | disclosed |
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-01-26 | — | — | US | disclosed |
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-01-26 | — | — | US | disclosed |
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | MSD K.K. (JP) | 2012-01-26 | — | — | US | disclosed |
| WO-2010117085-A1 | ARYL INDOLE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010117085-A1 | ARYL INDOLE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022078-A1 | ARYL INDOLE DERIVATIVES | IDO1, NAT1, IDO2 | CHRNB1 1514/4885CHRNB2 2588/4885CHRNB4 3362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.