Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556953 | 0.90 | POLB (0.52) | POLBNR4A1RAB9AGAABRAF | |
| SCHEMBL22417190 | 0.88 | DRD2 (0.59) | POLBNR4A1RAB9AGAADRD4 | |
| SCHEMBL16835012 | 0.87 | DRD4 (0.55) | POLBNR4A1RAB9AGAABRAF | |
| SCHEMBL28136923 | 0.84 | SMN1; SMN2 (0.57) | KMT2AMEN1L3MBTL1PRKCIDRD4 | |
| SCHEMBL4767684 | 0.82 | DRD2 (0.55) | DRD4DRD2DRD3 | |
| SCHEMBL28089268 | 0.82 | DRD4 (0.47) | POLBNR4A1RAB9AGAABRAF | |
| SCHEMBL10970617 | 0.81 | RAB9A (0.85) | POLBNR4A1RAB9AGAAKMT2A | |
| SCHEMBL5659857 | 0.81 | NAMPT (0.54) | RAB9ALMNADRD4DRD2DRD3 | |
| SCHEMBL17912996 | 0.80 | PRKCI (0.56) | BRAFPRKCIDRD4DRD2DRD3 | |
| SCHEMBL11752158 | 0.79 | POLB (0.66) | POLBNR4A1RAB9AGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227480-B2 | Indazole derivative having spiro ring structure in side chain | UBE INDUSTRIES, LTD. (JP) | 2012-07-24 | — | — | US | disclosed |
| US-20090170887-A1 | Novel indazole derivative having spiro ring structure in side chain | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-2025676-A1 | NOVEL INDAZOLE DERIVATIVE HAVING SPIRO RING STRUCTURE IN SIDE CHAIN | Ube Industries, Ltd. (JP) | 2009-02-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170887-A1 | Novel indazole derivative having spiro ring structure in side chain | CIT, ROCK1, ROCK2 | POLB 3306/4885NR4A1 1258/4885RAB9A 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.