Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790292 | 1.00 | LMNA (0.43) | LMNASMN1; SMN2KDM4EGLADGAT2 | |
| SCHEMBL4124909 | 1.00 | LMNA (0.43) | LMNASMN1; SMN2KDM4EGLADGAT2 | |
| SCHEMBL4130217 | 0.92 | DGAT2 (0.47) | LMNASMN1; SMN2KDM4EGLADGAT2 | |
| SCHEMBL4114345 | 0.92 | DGAT2 (0.47) | LMNASMN1; SMN2KDM4EGLADGAT2 | |
| SCHEMBL2085794 | 0.92 | DGAT2 (0.47) | LMNASMN1; SMN2KDM4EGLADGAT2 | |
| SCHEMBL4115998 | 0.88 | CNR1 (0.49) | LMNASMN1; SMN2KDM4EALDH1A1CNR1 | |
| SCHEMBL8984643 | 0.85 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2KDM4EGLADGAT2 | |
| SCHEMBL4115077 | 0.85 | CNR1 (0.43) | SMN1; SMN2KDM4EDGAT2ALDH1A1CNR1 | |
| SCHEMBL4120411 | 0.83 | DGAT2 (0.43) | LMNASMN1; SMN2KDM4EGLADGAT2 | |
| SCHEMBL4106949 | 0.83 | DGAT2 (0.42) | LMNASMN1; SMN2KDM4EGLADGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188097-B2 | Pyrazolo[1,5-A]pyrimidine compounds | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-05-29 | — | — | US | claimed |
| US-20090069298-A1 | Pyrazolo[1,5-A]Pyrimidine Compounds | TANABE SEIYAKU CO., LTD. (JP) | 2009-03-12 | — | — | US | claimed |
| US-8188097-B2 | Pyrazolo[1,5-A]pyrimidine compounds | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-05-29 | — | — | US | disclosed |
| US-20090069298-A1 | Pyrazolo[1,5-A]Pyrimidine Compounds | TANABE SEIYAKU CO., LTD. (JP) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069298-A1 | Pyrazolo[1,5-A]Pyrimidine Compounds | RECQL, QTRT1, DPYD | LMNA 3919/4885SMN1; SMN2 3307/4885KDM4E 2108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.