Sugi Predict

Sugi Predict / Compounds / SCHEMBL4125436

SCHEMBL4125436

SCHEMBL4125436

CC1=NS(=O)(=O)c2cc(-c3nc4cc(C(=O)NS(C)(=O)=O)ccc4n3C3CCCCC3)ccc2N1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ CYP3A4 P08684 3/20 0.39
▸ CYP1A2 P05177 2/20 0.39
▸ CYP2D6 P10635 2/20 0.39
▸ CYP2C9 P11712 2/20 0.39
▸ CYP2C19 P33261 2/20 0.39
▸ OGFRL1 Q5TC84 1/20 0.39
▸ RPS6KB1 P23443 1/20 0.39
▸ PTGER4 P35408 1/20 0.38
▸ TP53 P04637 2/20 0.38
▸ HDAC1 Q13547 1/20 0.37
▸ HDAC8 Q9BY41 1/20 0.37
▸ HDAC6 Q9UBN7 1/20 0.37
▸ BCAT2 O15382 2/20 0.37
▸ YEATS4 O95619 1/20 0.36
▸ KCNH2 Q12809 1/20 0.36
▸ SCN5A Q14524 1/20 0.36
▸ SCN9A Q15858 1/20 0.36
▸ THRB P10828 1/20 0.36
▸ IDH1 O75874 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4136984 0.88 L3MBTL1 (0.56) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL4124667 0.79 L3MBTL1 (0.43) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL4128261 0.78 ALDH1A1 (0.37) L3MBTL1CYP3A4CYP1A2CYP2D6RPS6KB1
SCHEMBL4131504 0.77 L3MBTL1 (0.46) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL13905096 0.77 L3MBTL1 (0.46) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL4130537 0.77 L3MBTL1 (0.46) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL4116743 0.77 PTGER4 (0.45) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL4509094 0.75 L3MBTL1 (0.43) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL4117358 0.75 L3MBTL1 (0.46) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL5438692 0.74 L3MBTL1 (0.46) L3MBTL1CYP3A4CYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050187390-A1 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. 2005-08-25 — — US claimed
US-7511145-B2 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. (US) 2009-03-31 — — US disclosed
US-7511145-B2 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. (US) 2009-03-31 — — US disclosed
US-7511145-B2 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. (US) 2009-03-31 — — US disclosed
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES GENELABS TECHNOLOGIES, INC. 2009-03-26 — — US disclosed
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES GENELABS TECHNOLOGIES, INC. 2009-03-26 — — US disclosed
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES GENELABS TECHNOLOGIES, INC. 2009-03-26 — — US disclosed
US-20050187390-A1 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. 2005-08-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES HAVCR2, MAVS, ZC3HAV1 L3MBTL1 1221/4885CYP3A4 52/4885CYP1A2 238/4885
US-20050187390-A1 Bicyclic heteroaryl derivatives HAVCR2, MAVS, ZC3HAV1 L3MBTL1 1221/4885CYP3A4 52/4885CYP1A2 238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.