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SCHEMBL4128261

SCHEMBL4128261

CC1=NS(=O)(=O)c2cc(-c3nc4cc(-c5nnn[nH]5)ccc4n3C3CCCCC3)ccc2N1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ THRB P10828 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ ABCC8 Q09428 1/20 0.37
▸ KCNJ11 Q14654 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ GFER P55789 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ CYP11B2 P19099 5/20 0.33
▸ OPRM1 P35372 5/20 0.33
▸ OPRL1 P41146 5/20 0.33
▸ CA12 O43570 1/20 0.33
▸ CA1 P00915 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4136984 0.83 L3MBTL1 (0.56) ALDH1A1LMNACYP1A2CYP3A4CYP2D6
SCHEMBL4125436 0.78 L3MBTL1 (0.42) CYP1A2CYP3A4CYP2D6THRBL3MBTL1
SCHEMBL4125421 0.78 CYP11B2 (0.39) ALDH1A1L3MBTL1KDM4EMAPTGFER
SCHEMBL4137491 0.78 CYP11B2 (0.41) ALDH1A1L3MBTL1KDM4EMAPTGFER
SCHEMBL4130964 0.77 CYP11B2 (0.38) ALDH1A1L3MBTL1KDM4EMAPTGFER
SCHEMBL4125031 0.77 KDM4E (0.36) ALDH1A1L3MBTL1KDM4EMAPTGFER
SCHEMBL4118354 0.76 CYP11B2 (0.42) ALDH1A1L3MBTL1KDM4EMAPTGFER
SCHEMBL13905028 0.76 CYP11B2 (0.42) ALDH1A1L3MBTL1KDM4EMAPTGFER
SCHEMBL4505966 0.76 L3MBTL1 (0.36) ALDH1A1L3MBTL1KDM4EMAPTGFER
SCHEMBL4116998 0.75 CYP11B2 (0.36) ALDH1A1LMNACYP1A2L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050187390-A1 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. 2005-08-25 — — US claimed
US-7511145-B2 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. (US) 2009-03-31 — — US disclosed
US-7511145-B2 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. (US) 2009-03-31 — — US disclosed
US-7511145-B2 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. (US) 2009-03-31 — — US disclosed
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES GENELABS TECHNOLOGIES, INC. 2009-03-26 — — US disclosed
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES GENELABS TECHNOLOGIES, INC. 2009-03-26 — — US disclosed
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES GENELABS TECHNOLOGIES, INC. 2009-03-26 — — US disclosed
US-20050187390-A1 Bicyclic heteroaryl derivatives GENELABS TECHNOLOGIES, INC. 2005-08-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090081165-A1 BICYCLIC HETEROARYL DERIVATIVES HAVCR2, MAVS, ZC3HAV1 ALDH1A1 2299/4885LMNA 1546/4885CYP1A2 238/4885
US-20050187390-A1 Bicyclic heteroaryl derivatives HAVCR2, MAVS, ZC3HAV1 ALDH1A1 2299/4885LMNA 1546/4885CYP1A2 238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.