Dimethylamine

Dimethylamine

SCHEMBL4125591

CNC.Cc1cc(OCc2ccc(C#N)cc2)cc2c(CCC3CCNCC3)noc12

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.39
HRH3 Q9Y5N1 1/20 0.38
KDM1A O60341 8/20 0.37
MAOB P27338 5/20 0.36
AKT1 P31749 1/20 0.36
SLC6A2 P23975 2/20 0.35
SLC6A4 P31645 2/20 0.35
SLC6A3 Q01959 2/20 0.35
KCNH2 Q12809 2/20 0.34
HTR3A P46098 1/20 0.34
MAOA P21397 1/20 0.34
NOS3 P29474 2/20 0.34
NOS1 P29475 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL4121481 0.86 ACHE (0.42) ACHEKDM1A
Dimethylamine SCHEMBL4127920 0.86 ACHE (0.59) ACHE
Dimethylamine SCHEMBL4126018 0.85 ACHE (0.58) ACHE
SCHEMBL4125583 0.85 ACHE (0.38) ACHEHRH3KDM1AMAOBAKT1
Dimethylamine SCHEMBL4126693 0.84 GPR119 (0.46) ACHE
Dimethylamine SCHEMBL4112593 0.83 ACHE (0.39) ACHEHRH3KDM1AMAOBAKT1
Dimethylamine SCHEMBL4122630 0.81 ACHE (0.38) ACHEKDM1AMAOBAKT1SLC6A2
Dimethylamine SCHEMBL4125191 0.76 ACHE (0.38) ACHEHRH3KDM1AMAOBAKT1
Dimethylamine SCHEMBL4121455 0.76 HTR6 (0.52) ACHEMAOBSLC6A4
SCHEMBL4132239 0.76 ACHE (0.40) ACHEHRH3KDM1AMAOBAKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090318690-A1 Benzisoxazole Compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-12-24 US disclosed
EP-2017275-A1 BENZISOXAZOLE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2009-01-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318690-A1 Benzisoxazole Compound NR1I2, NR1I3, NR0B1 ACHE 3716/4885HRH3 317/4885KDM1A 1437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.