Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130996 | 0.88 | PDE5A (0.41) | PDE5ACRHR1MTOR | |
| SCHEMBL4127685 | 0.87 | PDE5A (0.51) | PDE5AMEN1KMT2ACRHR1 | |
| SCHEMBL4132572 | 0.86 | MTOR (0.46) | PDE5AMEN1KMT2ACRHR1MTOR | |
| SCHEMBL4137351 | 0.85 | PDE5A (0.39) | PDE5AMEN1KMT2ACRHR1KDM5B | |
| SCHEMBL4123921 | 0.82 | PDE5A (0.42) | PDE5ACRHR1 | |
| SCHEMBL4143420 | 0.82 | CRHR1 (0.42) | PDE5ACRHR1MTOR | |
| SCHEMBL4140332 | 0.80 | CRHR1 (0.41) | PDE5ACRHR1 | |
| SCHEMBL4115556 | 0.79 | ALDH1A1 (0.41) | PDE5ACRHR1MTOR | |
| SCHEMBL4132060 | 0.78 | PDE5A (0.43) | PDE5AMEN1KMT2ACRHR1 | |
| SCHEMBL4120264 | 0.77 | CRHR1 (0.48) | PDE5AMEN1KMT2ACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | claimed |
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |