Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4120264 | 0.88 | CRHR1 (0.48) | PDE5ACRHR1MEN1ALDH1A1HPGD | |
| SCHEMBL4000244 | 0.86 | PDE5A (0.46) | PDE5ACRHR1MEN1ALDH1A1HPGD | |
| SCHEMBL4127685 | 0.85 | PDE5A (0.51) | PDE5ACRHR1MEN1ALDH1A1HPGD | |
| SCHEMBL4138719 | 0.82 | PDE5A (0.39) | PDE5ACRHR1MEN1ALDH1A1HPGD | |
| SCHEMBL4143420 | 0.80 | CRHR1 (0.42) | PDE5ACRHR1ALDH1A1KDM4E | |
| SCHEMBL4136240 | 0.79 | CRHR1 (0.39) | PDE5ACRHR1MEN1ALDH1A1HPGD | |
| SCHEMBL4140332 | 0.79 | CRHR1 (0.41) | PDE5ACRHR1 | |
| SCHEMBL4123921 | 0.79 | PDE5A (0.42) | PDE5ACRHR1 | |
| SCHEMBL4130996 | 0.78 | PDE5A (0.41) | PDE5ACRHR1 | |
| SCHEMBL4126045 | 0.78 | PDE5A (0.41) | PDE5ACRHR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | claimed |
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |