Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123921 | 0.85 | PDE5A (0.42) | CRHR1PDE5A | |
| SCHEMBL4127685 | 0.84 | PDE5A (0.51) | CRHR1PDE5A | |
| SCHEMBL4143420 | 0.83 | CRHR1 (0.42) | CRHR1PDE5A | |
| SCHEMBL4126045 | 0.80 | PDE5A (0.41) | CRHR1PDE5A | |
| SCHEMBL4115556 | 0.80 | ALDH1A1 (0.41) | CRHR1PDE5A | |
| SCHEMBL4129126 | 0.79 | PDE5A (0.40) | CRHR1PDE5A | |
| SCHEMBL4132060 | 0.79 | PDE5A (0.43) | CRHR1PDE5A | |
| SCHEMBL4130996 | 0.78 | PDE5A (0.41) | CRHR1PDE5A | |
| SCHEMBL4136240 | 0.78 | CRHR1 (0.39) | CRHR1PDE5A | |
| SCHEMBL4132572 | 0.77 | MTOR (0.46) | CRHR1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | claimed |
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |