Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856513 | 0.81 | PDK1 (0.35) | LMNAPDK1SLC22A6SLC22A8SLC22A12 | |
| SCHEMBL29221672 | 0.81 | LMNA (0.43) | LMNASLC22A6SLC22A8SLC22A12CYP11B2 | |
| SCHEMBL23407655 | 0.79 | NOTUM (0.54) | LMNACYP11B2NOTUMMAPT | |
| SCHEMBL303424 | 0.78 | LMNA (0.46) | LMNAPDK1SLC22A6SLC22A8SLC22A12 | |
| SCHEMBL304544 | 0.78 | PDK1 (0.43) | LMNAPDK1SLC22A6SLC22A8SLC22A12 | |
| SCHEMBL25735599 | 0.76 | PKM (0.36) | LMNAPKMMAOBBACE1 | |
| SCHEMBL20564040 | 0.73 | ALDH1A1 (0.45) | CYP11B2PKMNOTUMALDH1A1L3MBTL1 | |
| SCHEMBL30955813 | 0.73 | EGFR (0.43) | LMNASLC22A6SLC22A8SLC22A12PKM | |
| SCHEMBL31693942 | 0.70 | EGFR (0.43) | LMNASLC22A6SLC22A8SLC22A12PKM | |
| SCHEMBL21603255 | 0.70 | EGFR (0.43) | LMNASLC22A6SLC22A8SLC22A12PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071895-A1 | FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |