Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 3/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660167 | 0.91 | ALDH1A1 (0.46) | ALDH1A1ALOX5CYP2C9CYP2C19HPGD | |
| SCHEMBL4662730 | 0.81 | ACP3 (0.43) | ALDH1A1ALOX5CYP2C9CYP2C19HPGD | |
| SCHEMBL4663676 | 0.81 | ALDH1A1 (0.43) | ALDH1A1ALOX5CYP2C9CYP2C19HPGD | |
| SCHEMBL4660065 | 0.81 | GAA (0.46) | ALDH1A1HPGDSLC6A4GAAL3MBTL1 | |
| SCHEMBL4661572 | 0.80 | ALDH1A1 (0.39) | ALDH1A1ALOX5CYP2C9CYP2C19HPGD | |
| SCHEMBL4661478 | 0.80 | ACP3 (0.41) | ALDH1A1ALOX5CYP2C9CYP2C19HPGD | |
| SCHEMBL4278073 | 0.78 | CASP1 (0.39) | ALDH1A1CYP2C9CYP2C19HPGDHTT | |
| SCHEMBL4661637 | 0.77 | CMA1 (0.42) | ALDH1A1ALOX5CYP2C9CYP2C19HPGD | |
| SCHEMBL4660270 | 0.77 | MEN1 (0.40) | ALDH1A1ALOX5CYP2C9CYP2C19HPGD | |
| SCHEMBL4661578 | 0.77 | MAPT (0.42) | ALDH1A1HPGDKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476752-B2 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters | WYETH (US) | 2009-01-13 | — | — | US | disclosed |
| WO-2005123663-A1 | PROCESSES FOR THE PREPARATION OF 2-CYANO-3-NAPHTHALENE-1-YL-3-PHENYL-PROPIONIC ACID ALKYL OR BENZYL ESTERS | WYETH (US) | 2005-12-29 | — | — | WO | disclosed |
| WO-2005123664-A2 | PROCESSES FOR THE PREPARATION OF 2-CYANO-3-NAPHTHALENE-1-YL-ACRYLIC ACID ALKYL OR BENZYL ESTERS | WYETH (US) | 2005-12-29 | — | — | WO | disclosed |
| US-20050277783-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters | WYETH (US) | 2005-12-15 | — | — | US | disclosed |
| US-20050277784-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-acrylic acid alkyl or benzyl esters | WYETH (US) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277783-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters | PCCA, PAH, CYP7A1 | ALDH1A1 189/4885ALOX5 182/4885CYP2C9 38/4885 |
| US-20050277784-A1 | Processes for the preparation of 2-cyano-3-naphthalene-1-yl-acrylic acid alkyl or benzyl esters | TNF, ACACA, PCCA | ALDH1A1 453/4885ALOX5 59/4885CYP2C9 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.