Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.46 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.46 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12106085 | 0.90 | MEN1 (0.52) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL10907589 | 0.89 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL64440 | 0.88 | MEN1 (0.56) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL342127 | 0.88 | TSHR (0.52) | ALDH1A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL26558194 | 0.87 | MAPT (0.61) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| Hydrochloric Acid SCHEMBL2121314 | 0.86 | MAPT (0.54) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL3349361 | 0.83 | KEAP1 (0.51) | ALDH1A1MEN1KMT2AMAPTNOX1 | |
| SCHEMBL8483627 | 0.83 | ESRRG (0.48) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL8373779 | 0.83 | MAPT (0.50) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL1132513 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748445-B2 | Methods for treating glioma | THE UAB RESEARCH FOUNDATION (US) | 2014-06-10 | — | — | US | disclosed |
| US-20090117031-A1 | Methods for Treating Glioma | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2009-05-07 | — | — | US | disclosed |
| EP-1824564-A2 | METHOD FOR TREATING GLIOMA | THE UAB RESEARCH FOUNDATION (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006049957-A2 | METHOD FOR TREATING GLIOMA | THE UAB RESEARCH FOUNDATION (US) | 2006-05-11 | — | — | WO | disclosed |