Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 12/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL4114239 | 0.95 | ACHE (0.57) | ACHEBCHECHRM4CHRM2CHRM5 | |
| Fumaric Acid SCHEMBL4132491 | 0.91 | ACHE (0.52) | ACHEBCHECHRM4CHRM2 | |
| Fumaric Acid SCHEMBL4128297 | 0.89 | ACHE (0.50) | ACHEBCHECHRM4CHRM2CHRM5 | |
| Fumaric Acid SCHEMBL4128304 | 0.89 | ACHE (0.50) | ACHEBCHECHRM4CHRM2CHRM5 | |
| Fumaric Acid SCHEMBL4121759 | 0.88 | ACHE (0.51) | ACHEBCHECHRM2 | |
| Dimethylamine SCHEMBL4126864 | 0.86 | ACHE (0.39) | ACHEBCHECHRM4CHRM2CHRM5 | |
| Dimethylamine SCHEMBL4120502 | 0.86 | ACHE (0.60) | ACHEBCHE | |
| Dimethylamine SCHEMBL4121343 | 0.86 | ACHE (0.57) | ACHEBCHECHRM4CHRM2 | |
| Dimethylamine SCHEMBL4125696 | 0.86 | ACHE (0.59) | ACHEBCHE | |
| Dimethylamine SCHEMBL4120900 | 0.85 | ACHE (0.56) | ACHEBCHECHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
| EP-2017275-A1 | BENZISOXAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2009-01-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | NR1I2, NR1I3, NR0B1 | CHRM2 165/4885ACHE 3716/4885BCHE 2215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.