Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4127026 | 0.78 | LMNA (0.44) | LMNAMAPK1MAPTKDM4ECISD2 | |
| SCHEMBL6397110 | 0.77 | CISD2 (0.42) | LMNAMAPK1MAPTKDM4ECISD2 | |
| SCHEMBL3205578 | 0.66 | LCK (0.42) | LMNAMAPK1MAPTKDM4EALDH1A1 | |
| SCHEMBL20554293 | 0.65 | ALDH1A1 (0.46) | MAPTALDH1A1STING1KMT2A | |
| SCHEMBL7399022 | 0.64 | MAPT (0.50) | LMNAMAPTKDM4EALDH1A1POLB | |
| SCHEMBL11107469 | 0.63 | HPGD (0.40) | LMNAMAPK1MAPTKDM4ECISD2 | |
| SCHEMBL20094461 | 0.63 | ALDH1A1 (0.45) | LMNAMAPK1MAPTKDM4EALDH1A1 | |
| SCHEMBL7263716 | 0.63 | PKM (0.58) | LMNAKDM4EALDH1A1POLBHPGD | |
| SCHEMBL27760680 | 0.62 | MAPT (0.40) | LMNAMAPK1MAPTKDM4ECISD2 | |
| SCHEMBL12251385 | 0.62 | LMNA (0.62) | LMNAMAPTALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | LMNA 4856/4885MAPK1 302/4885MAPT 3303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.