Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | YES1 | P07947 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134597 | 0.96 | HDAC1 (0.37) | HPGDHDAC1HDAC8HDAC6CYP11B2 | |
| SCHEMBL4131496 | 0.89 | HDAC1 (0.37) | HDAC1HDAC8HDAC6CYP11B2CYP11B1 | |
| SCHEMBL4129327 | 0.85 | L3MBTL1 (0.34) | HDAC1HDAC8HDAC6CYP11B2CYP11B1 | |
| SCHEMBL6398862 | 0.84 | CYP11B2 (0.38) | HDAC1HDAC8HDAC6CYP11B2CYP11B1 | |
| SCHEMBL4137491 | 0.84 | CYP11B2 (0.41) | HDAC1HDAC8HDAC6CYP11B2CYP11B1 | |
| SCHEMBL13904996 | 0.84 | OPRK1 (0.45) | HPGDHDAC1HDAC8HDAC6CYP11B2 | |
| SCHEMBL6397709 | 0.84 | CYP11B2 (0.40) | HDAC1HDAC8HDAC6CYP11B2CYP11B1 | |
| SCHEMBL4116973 | 0.81 | L3MBTL1 (0.56) | HPGDHDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL5797566 | 0.81 | PRKACA (0.41) | HDAC1HDAC8HDAC6CYP11B2CYP11B1 | |
| SCHEMBL13904993 | 0.81 | OPRK1 (0.45) | HPGDHDAC1HDAC8HDAC6CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187390-A1 | Bicyclic heteroaryl derivatives | GENELABS TECHNOLOGIES, INC. | 2005-08-25 | — | — | US | claimed |
| US-20090081165-A1 | BICYCLIC HETEROARYL DERIVATIVES | GENELABS TECHNOLOGIES, INC. | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090081165-A1 | BICYCLIC HETEROARYL DERIVATIVES | HAVCR2, MAVS, ZC3HAV1 | HPGD 3746/4885HDAC1 358/4885HDAC8 693/4885 |
| US-20050187390-A1 | Bicyclic heteroaryl derivatives | HAVCR2, MAVS, ZC3HAV1 | HPGD 3746/4885HDAC1 358/4885HDAC8 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.