⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium SCHEMBL5942216 | 0.86 | — | — | |
| SCHEMBL13767713 | 0.79 | RPS6KB1 (0.31) | — | |
| SCHEMBL2934571 | 0.76 | DGAT1 (0.36) | — | |
| SCHEMBL5943082 | 0.75 | KDM4E (0.35) | — | |
| SCHEMBL4131019 | 0.75 | XDH (0.34) | — | |
| SCHEMBL1858741 | 0.74 | DGAT1 (0.37) | — | |
| Potassium Ion SCHEMBL1857290 | 0.68 | DGAT1 (0.36) | — | |
| SCHEMBL19926316 | 0.64 | MAPK1 (0.33) | — | |
| SCHEMBL20569880 | 0.64 | ADA (0.34) | — | |
| SCHEMBL1857062 | 0.64 | DGAT1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557847-B2 | Synergistic modulation of FLT3 kinase using a FLT3 inhibitor and a farnesyl transferase inhibitor | JANSSEN PHARMACEUTICA, N.V. (BE) | 2013-10-15 | — | — | US | disclosed |
| US-20090197913-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR | BAUMANN CHRISTIAN ANDREW | 2009-08-06 | — | — | US | disclosed |