Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | CD38 | P28907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134627 | 0.92 | MAPT (0.34) | MAPTCNR2ALDH1A1PDE5APDE6C | |
| SCHEMBL4127434 | 0.86 | KDM4E (0.35) | MAPTCNR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4123024 | 0.85 | ALDH1A1 (0.36) | MAPTALDH1A1PDE5APDE6CALOX15 | |
| SCHEMBL4140662 | 0.85 | KDM4E (0.35) | MAPTCNR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4122386 | 0.84 | KDM4E (0.36) | MAPTCNR2ALDH1A1PDE5AKDM4E | |
| SCHEMBL8045132 | 0.84 | KDM4E (0.41) | MAPTCNR2ALDH1A1PDE5AKDM4E | |
| SCHEMBL8034133 | 0.82 | KDM4E (0.36) | MAPTALDH1A1PDE5APDE6CHSD17B10 | |
| SCHEMBL4128827 | 0.82 | KDM4E (0.39) | MAPTCNR2ALDH1A1PDE5AKDM4E | |
| SCHEMBL4139405 | 0.80 | KDM4E (0.34) | MAPTALDH1A1KDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL3995952 | 0.80 | KDM4E (0.39) | MAPTALDH1A1KDM4ESMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |