Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.75 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | NAMPT | P43490 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294845 | 1.00 | HDAC3 (0.75) | HDAC3HDAC6HDAC11HDAC8TRPV1 | |
| SCHEMBL7303163 | 0.93 | HDAC3 (0.86) | HDAC3HDAC6HDAC11HDAC8TRPV1 | |
| SCHEMBL23352874 | 0.89 | HDAC3 (0.75) | HDAC3HDAC6HDAC11HDAC8TRPV1 | |
| SCHEMBL7296645 | 0.89 | HDAC3 (0.75) | HDAC3HDAC6HDAC11HDAC8TRPV1 | |
| SCHEMBL6459176 | 0.89 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3873116 | 0.86 | NR1H4 (0.81) | HDAC3HDAC6HDAC11HDAC8TRPV1 | |
| SCHEMBL7301362 | 0.86 | HDAC3 (0.75) | HDAC3HDAC6HDAC11HDAC8TRPV1 | |
| SCHEMBL1687867 | 0.86 | NPC1 (0.79) | HDAC3HDAC6HDAC11HDAC8TRPV1 | |
| SCHEMBL7293270 | 0.86 | HDAC3 (0.75) | HDAC3HDAC6HDAC11HDAC8TRPV1 | |
| SCHEMBL7291713 | 0.86 | NPC1 (0.79) | HDAC3HDAC6HDAC11HDAC8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163549-A1 | Pharmaceutical Composition Comprising an Amide Derivative | SHIONOGI & CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| US-20090163549-A1 | Pharmaceutical Composition Comprising an Amide Derivative | SHIONOGI & CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| US-20090163549-A1 | Pharmaceutical Composition Comprising an Amide Derivative | SHIONOGI & CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| EP-1959944-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING AN AMIDE DERIVATIVE | Shionogi Co., Ltd. (JP) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007069773-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING AN AMIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007069773-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING AN AMIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163549-A1 | Pharmaceutical Composition Comprising an Amide Derivative | TRPV1, TRPA1, TRPV2 | HDAC3 344/4885HDAC6 298/4885HDAC11 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.