Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4131996 | 1.00 | KCNH2 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3TGFBR1 | |
| SCHEMBL4133233 | 0.88 | SLC6A2 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4133227 | 0.88 | SLC6A2 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4136235 | 0.84 | SLC6A2 (0.44) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4136227 | 0.84 | SLC6A2 (0.44) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4127777 | 0.84 | HTR7 (0.47) | KCNH2SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL4127782 | 0.84 | HTR7 (0.47) | KCNH2SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL4132660 | 0.83 | NAAA (0.44) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4132656 | 0.83 | NAAA (0.44) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4140686 | 0.83 | SLC6A2 (0.49) | KCNH2SLC6A2SLC6A4SLC6A3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | PFIZER PRODUCTS INC. (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | OPRL1, HTR5A, OPRD1 | KCNH2 673/4885SLC6A2 28/4885SLC6A4 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.