Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.39 |
| ▸ | PDE5A | O76074 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4127685 | 0.82 | PDE5A (0.51) | CRHR1PDE5AMAPTMEN1ALDH1A1 | |
| SCHEMBL4143420 | 0.81 | CRHR1 (0.42) | CRHR1PDE5AMAPTALDH1A1MTOR | |
| SCHEMBL4132060 | 0.79 | PDE5A (0.43) | CRHR1PDE5AMEN1ALDH1A1HPGD | |
| SCHEMBL4000244 | 0.79 | PDE5A (0.46) | CRHR1PDE5AMEN1ALDH1A1HPGD | |
| SCHEMBL4120264 | 0.78 | CRHR1 (0.48) | CRHR1PDE5AMEN1ALDH1A1HPGD | |
| SCHEMBL4115556 | 0.78 | ALDH1A1 (0.41) | CRHR1PDE5AMAPTALDH1A1HPGD | |
| SCHEMBL4140332 | 0.78 | CRHR1 (0.41) | CRHR1PDE5A | |
| SCHEMBL4123921 | 0.78 | PDE5A (0.42) | CRHR1PDE5A | |
| SCHEMBL4132572 | 0.77 | MTOR (0.46) | CRHR1PDE5AMEN1ALDH1A1HPGD | |
| SCHEMBL4126045 | 0.77 | PDE5A (0.41) | CRHR1PDE5AMEN1KMT2AMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | claimed |
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071705-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |