Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | SLC9A3 | P48764 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198903 | 1.00 | TACR1 (0.42) | TACR1TAAR1SLC9A3HTR6HTR1A | |
| SCHEMBL5198894 | 1.00 | TACR1 (0.42) | TACR1TAAR1SLC9A3HTR6HTR1A | |
| Hydrochloric Acid SCHEMBL4127586 | 0.99 | TACR1 (0.42) | TACR1TAAR1SLC9A3HTR6HTR1A | |
| Hydrochloric Acid SCHEMBL4127599 | 0.99 | TACR1 (0.42) | TACR1TAAR1SLC9A3HTR6HTR1A | |
| Hydrochloric Acid SCHEMBL4127603 | 0.99 | TACR1 (0.42) | TACR1TAAR1SLC9A3HTR6HTR1A | |
| SCHEMBL5198136 | 0.93 | TACR1 (0.37) | TACR1TAAR1 | |
| SCHEMBL5198139 | 0.93 | TACR1 (0.37) | TACR1TAAR1 | |
| Hydrochloric Acid SCHEMBL4126780 | 0.92 | TACR1 (0.36) | TACR1TAAR1 | |
| Hydrochloric Acid SCHEMBL4126783 | 0.92 | TACR1 (0.36) | TACR1TAAR1 | |
| SCHEMBL5198838 | 0.87 | HTR1A (0.42) | TACR1TAAR1SLC9A3HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465733-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2008-12-16 | — | — | US | claimed |
| EP-1710240-B1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | SERVIER LAB (FR) | 2007-12-05 | — | — | EP | claimed |
| US-20060229318-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | US | claimed |
| EP-1710240-A1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | Les Laboratoires Servier (FR) | 2006-10-11 | — | — | EP | claimed |
| US-7612061-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-11-03 | — | — | US | disclosed |
| US-20090076030-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-03-19 | — | — | US | disclosed |
| US-20090075982-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-03-19 | — | — | US | disclosed |
| US-7465733-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2008-12-16 | — | — | US | disclosed |
| EP-1710240-B1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | SERVIER LAB (FR) | 2007-12-05 | — | — | EP | disclosed |
| US-20060229318-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | US | disclosed |
| EP-1710240-A1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | Les Laboratoires Servier (FR) | 2006-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075982-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | TACR1 45/4885TAAR1 77/4885SLC9A3 2096/4885 |
| US-20090076030-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | TACR1 45/4885TAAR1 77/4885SLC9A3 2096/4885 |
| US-20060229318-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | TACR1 45/4885TAAR1 77/4885SLC9A3 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.