Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 18/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915576 | 0.91 | RAB9A (0.42) | TRPV4ITGA1 | |
| Hydrochloric Acid SCHEMBL4136144 | 0.85 | CCR1 (0.45) | TRPV4CCR1 | |
| SCHEMBL4140203 | 0.82 | ADAM17 (0.42) | TRPV4CCR1 | |
| SCHEMBL4135643 | 0.82 | TRPV4 (0.47) | TRPV4 | |
| SCHEMBL4136296 | 0.81 | RAB9A (0.45) | TRPV4 | |
| SCHEMBL4135954 | 0.78 | CTSL (0.43) | TRPV4 | |
| SCHEMBL4131127 | 0.77 | RAB9A (0.39) | TRPV4 | |
| SCHEMBL4135952 | 0.76 | TRPV4 (0.41) | TRPV4ITGA1 | |
| SCHEMBL3915580 | 0.72 | RAB9A (0.42) | TRPV4ITGA1 | |
| SCHEMBL4777734 | 0.72 | TRPV4 (0.55) | TRPV4CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
| EP-1940785-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | TRPV4, TRPC4, TRPV1 | TRPV4 1/4885CCR1 766/4885ITGA1 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.