Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | ACP3 | P15309 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473252 | 0.85 | CASR (0.50) | KMT2AMEN1MAPTTDP1ACP3 | |
| SCHEMBL10552240 | 0.85 | CASR (0.51) | KMT2AMEN1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL5782693 | 0.84 | MEN1 (0.58) | KMT2AMEN1ALDH1A1TDP1MAOB | |
| SCHEMBL4135956 | 0.83 | PNMT (0.65) | PNMTMAPTALDH1A1CES2ACP3 | |
| SCHEMBL4135655 | 0.82 | PNMT (0.59) | KMT2AMEN1PNMTMAPTALDH1A1 | |
| SCHEMBL11193839 | 0.82 | ALDH1A1 (0.48) | KMT2AMEN1PNMTMAPTALDH1A1 | |
| SCHEMBL2010410 | 0.82 | IDO1 (0.47) | KMT2AMEN1PNMTMAPTALDH1A1 | |
| SCHEMBL10889071 | 0.81 | PNMT (0.54) | KMT2AMEN1PNMTMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL2013413 | 0.81 | IDO1 (0.49) | KMT2AMEN1PNMTMAPTALDH1A1 | |
| SCHEMBL28519052 | 0.79 | MEN1 (0.51) | KMT2AMEN1MAPTTDP1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377578-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1983-03-22 | — | — | US | disclosed |
| US-4250176-A | BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-02-10 | — | — | US | disclosed |
| US-4200641-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1980-04-29 | — | — | US | disclosed |