Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130771 | 0.83 | ALDH1A1 (0.42) | ALDH1A1FFAR4 | |
| SCHEMBL4135820 | 0.79 | ALDH1A1 (0.44) | ALDH1A1ALDH1A3FFAR4 | |
| SCHEMBL4136516 | 0.79 | HRH3 (0.47) | FFAR4 | |
| SCHEMBL4123180 | 0.76 | HRH3 (0.39) | ALDH1A1FFAR4MEN1KMT2A | |
| SCHEMBL4141352 | 0.76 | FFAR4 (0.48) | ALDH1A1FFAR4 | |
| SCHEMBL4135581 | 0.72 | TLR9 (0.38) | FFAR4ADRA1APOLB | |
| SCHEMBL16440170 | 0.70 | ALDH1A1 (0.56) | ALDH1A1ALDH1A3DRD2HTR1AADRA1D | |
| SCHEMBL4140025 | 0.70 | SCD (0.40) | MAPTMEN1KMT2A | |
| SCHEMBL4135176 | 0.68 | HRH3 (0.38) | FFAR4 | |
| SCHEMBL4146899 | 0.68 | KDM2B (0.45) | ALDH1A1FFAR4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021004-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-02-11 | — | — | EP | claimed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | claimed |