Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4135892 | 1.00 | NPC1 (0.48) | NPC1RAB9AKDM4ETAAR1CNR1 | |
| SCHEMBL4135882 | 1.00 | NPC1 (0.48) | NPC1RAB9AKDM4ETAAR1CNR1 | |
| SCHEMBL14045177 | 0.80 | NPC1 (0.58) | NPC1RAB9AKDM4ETAAR1CNR1 | |
| SCHEMBL14241867 | 0.78 | TAAR1 (0.56) | RAB9ATAAR1CNR1TRPV1L3MBTL1 | |
| SCHEMBL1010476 | 0.78 | MTNR1A (0.61) | NPC1RAB9AKDM4ETAAR1CNR1 | |
| SCHEMBL4152840 | 0.78 | RAB9A (0.45) | NPC1RAB9AKDM4ETAAR1CNR1 | |
| SCHEMBL4152846 | 0.78 | RAB9A (0.45) | NPC1RAB9AKDM4ETAAR1CNR1 | |
| SCHEMBL4135175 | 0.76 | TAAR1 (0.49) | TAAR1CNR1KMT2AMEN1 | |
| SCHEMBL4135180 | 0.76 | TAAR1 (0.49) | TAAR1CNR1KMT2AMEN1 | |
| SCHEMBL4135179 | 0.76 | TAAR1 (0.49) | TAAR1CNR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | NPC1 503/4885RAB9A 1457/4885KDM4E 4712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.