Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 15/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447814 | 0.87 | GBA1 (0.59) | TRPV4CCR1GBA1TDO2 | |
| SCHEMBL5447807 | 0.87 | GBA1 (0.59) | TRPV4CCR1GBA1TDO2 | |
| SCHEMBL14360846 | 0.80 | CCR1 (0.52) | TRPV4CCR1TDO2MGAM | |
| SCHEMBL4132403 | 0.79 | BRD4 (0.46) | TRPV4CCR1BMP1MGAM | |
| SCHEMBL4141122 | 0.79 | CYP3A4 (0.56) | TRPV4CCR1TDO2 | |
| SCHEMBL4140210 | 0.73 | BMP1 (0.45) | TRPV4CCR1GBA1BMP1 | |
| SCHEMBL4140203 | 0.73 | ADAM17 (0.42) | TRPV4CCR1GBA1BMP1 | |
| SCHEMBL13872427 | 0.73 | HTT (0.45) | TRPV4CCR1BMP1 | |
| SCHEMBL5433686 | 0.73 | GBA1 (0.55) | TRPV4CCR1GBA1 | |
| SCHEMBL14360908 | 0.73 | GBA1 (0.55) | TRPV4CCR1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | TRPV4, TRPC4, TRPV1 | TRPV4 1/4885CCR1 766/4885GBA1 1687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.