Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 9/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.56 |
| ▸ | TP53 | P04637 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | THPO | P40225 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | GMNN | O75496 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | FPR2 | P25090 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14360846 | 0.96 | CCR1 (0.52) | CYP3A4CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL7010992 | 0.85 | MEN1 (0.53) | CYP3A4CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL4128136 | 0.85 | CYP3A4 (0.58) | CYP3A4CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL7005708 | 0.85 | MEN1 (0.53) | CYP3A4CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL4136570 | 0.79 | TRPV4 (0.49) | CCR1TDO2TRPV4 | |
| SCHEMBL2010514 | 0.76 | ALOX5AP (0.48) | MEN1KMT2AALDH1A1LMNACCR1 | |
| SCHEMBL5441643 | 0.76 | CNR2 (0.48) | CYP3A4CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL7213002 | 0.76 | ACLY (0.49) | ALDH1A1FABP4 | |
| SCHEMBL4140295 | 0.76 | BMP1 (0.51) | CCR1TRPV4CNR1CNR2FABP4 | |
| SCHEMBL5447807 | 0.75 | GBA1 (0.59) | ALDH1A1CCR1PKMTDO2TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | TRPV4, TRPC4, TRPV1 | CYP3A4 1672/4885CYP1A2 3159/4885CYP2C9 3459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.