Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13202892 | 0.87 | ALDH1A1 (0.76) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL10167539 | 0.87 | ALDH1A1 (0.97) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL610143 | 0.84 | ALDH1A1 (0.76) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL3126859 | 0.84 | ALDH1A1 (0.76) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL18171334 | 0.84 | AIMP2 (0.81) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL18171335 | 0.83 | AIMP2 (0.80) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL2550825 | 0.83 | GAA (0.74) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL31235619 | 0.83 | ALDH1A1 (0.74) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL8335181 | 0.83 | ALDH1A1 (0.74) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL12593464 | 0.83 | ALDH1A1 (0.74) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612061-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-11-03 | — | — | US | disclosed |
| US-20090076030-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-03-19 | — | — | US | disclosed |
| US-20090075982-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-03-19 | — | — | US | disclosed |
| US-7465733-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2008-12-16 | — | — | US | disclosed |
| EP-1710240-B1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | SERVIER LAB (FR) | 2007-12-05 | — | — | EP | disclosed |
| US-20060229318-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | US | disclosed |
| WO-2006106241-A1 | PIPERAZINE DERIVATIVES AND USE THEREOF AS SEROTONIN REUPTAKE INHIBITORS OR AS NEUROKININ ANTAGONISTS | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | WO | disclosed |
| EP-1710240-A1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | Les Laboratoires Servier (FR) | 2006-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075982-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | ALDH1A1 1565/4885HPGD 1704/4885SMN1; SMN2 3546/4885 |
| US-20090076030-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | ALDH1A1 1565/4885HPGD 1704/4885SMN1; SMN2 3546/4885 |
| US-20060229318-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | ALDH1A1 1565/4885HPGD 1704/4885SMN1; SMN2 3546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.