Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31235619 | 1.00 | ALDH1A1 (0.74) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL610143 | 0.99 | ALDH1A1 (0.76) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL11483389 | 0.93 | ALDH1A1 (0.78) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL13916514 | 0.86 | ALDH1A1 (0.62) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL10167539 | 0.84 | ALDH1A1 (0.97) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL4136572 | 0.83 | ALDH1A1 (0.78) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL13916512 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL13202892 | 0.82 | ALDH1A1 (0.76) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL3126859 | 0.82 | ALDH1A1 (0.76) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA | |
| SCHEMBL12593464 | 0.81 | ALDH1A1 (0.74) | ALDH1A1HPGDSMN1; SMN2KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919931-A | Process for the manufacture of intermediates suitable to make doxazosin, terazosin, prazosin, tiodazosin and related antihypertensive medicines | BRANTFORD CHEMICALS INC. (CA) | 1999-07-06 | — | — | US | claimed |
| CN-102321080-B | Doxazosin mesylate V form crystal, and preparation method and usage thereof | NCPC NEW DRUG RES & DEV CO LTD | 2013-09-25 | — | — | CN | disclosed |
| CN-102260250-B | (-) doxazosin mesylate type IV crystal as well as preparation method and application thereof | NCPC NEW DRUG RES & DEV CO LTD | 2013-09-25 | — | — | CN | disclosed |
| CN-102321078-B | Doxazosin mesylate III form crystal, and preparation method and usage thereof | NCPC NEW DRUG RES & DEV CO LTD | 2013-08-28 | — | — | CN | disclosed |
| CN-102321079-B | (-) doxazosin mesylate crystal VI as well as preparation method and application thereof | NCPC NEW DRUG RES & DEV CO LTD | 2013-08-28 | — | — | CN | disclosed |
| CN-102321078-A | Doxazosin mesylate III form crystal, and preparation method and usage thereof | NCPC NEW DRUG RES & DEV CO LTD | 2012-01-18 | — | — | CN | disclosed |
| CN-102321080-A | Doxazosin mesylate V form crystal, and preparation method and usage thereof | NCPC NEW DRUG RES & DEV CO LTD | 2012-01-18 | — | — | CN | disclosed |
| CN-102321079-A | (-) doxazosin mesylate crystal VI as well as preparation method and application thereof | NCPC NEW DRUG RES & DEV CO LTD | 2012-01-18 | — | — | CN | disclosed |
| CN-102260249-A | (-) doxazosin mesylate type II crystal as well as preparation method and application thereof | — | 2011-11-30 | — | — | CN | disclosed |
| CN-102260250-A | (-) doxazosin mesylate type IV crystal as well as preparation method and application thereof | — | 2011-11-30 | — | — | CN | disclosed |
| CN-100999519-A | Doxazosin mesylate, preparation method and application thereof | NEW MEDICINE RES DEV CO LTD HU (CN) | 2007-07-18 | — | — | CN | disclosed |
| CN-1769285-A | Doxazosin salt with optical activity | NCPC NEW DRUG RES AND DEV CO L (CN) | 2006-05-10 | — | — | CN | disclosed |
| CN-1746168-A | Optically active doxazosin salt | HUABEI PHARMACEUTICAL GROUP NE (CN) | 2006-03-15 | — | — | CN | disclosed |
| US-5919931-A | Process for the manufacture of intermediates suitable to make doxazosin, terazosin, prazosin, tiodazosin and related antihypertensive medicines | BRANTFORD CHEMICALS INC. (CA) | 1999-07-06 | — | — | US | disclosed |
| EP-0028473-B1 | CHLORO- AND ALKOXY-SUBSTITUTED-2,4-DIAMINOQUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1985-01-09 | — | — | EP | disclosed |
| US-4377581-A | ANTIHYPERTENSIVE AGENTS | PFIZER INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4351940-A | Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4287341-A | USEFUL AS ANTIHYPERTENSIVE AGENTS | PFIZER INC. (US) | 1981-09-01 | — | — | US | disclosed |
| EP-0028473-A1 | Chloro- and alkoxy-substituted-2,4-diaminoquinazolines and pharmaceutical compositions containing them | PFIZER INC. (US) | 1981-05-13 | — | — | EP | disclosed |
| US-4188390-A | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines | PFIZER INC. (US) | 1980-02-12 | — | — | US | disclosed |